July 2023 Newsletter

Could NAD+ and NMN Help Improve Egg Quality & Fertility?

We know that age is one of the biggest contributors to delays to conception and the increased need for fertility treatments, but sadly, we are yet to find the time machine for our gametes – eggs and sperm to reverse age these to improve their quality to conceive.

Whilst, we can’t control our age, we can change how we look after our bodies and thus the eggs and sperm within them, and there may be a promising new nutrient that may help with age- related infertility. There has been a lot of talk about NAD+/NMN in the fertility space over the last couple of years. So what is NAD+, and should you be taking a supplement like NMN to increase your NAD+?

What Is NAD+/NMN?

NAD+ or nicotinamide adenine dinucleotide is a co-enzyme required for a number of reactions to occur in the body. As we get older our levels of NAD+ decreases and this decline in NAD+ levels is linked to numerous aging- associated processes and diseases. Some of these can be slowed down and even reversed by restoring NAD+ levels.

This is of particular interest to those of us looking to improve egg quality, which also declines naturally with age.

What Is The Role Of NAD+ In The Body?

Each cell in the body has mitochondria – also known as the powerhouse of the cell, and this is where we will find NAD+. Because NAD+ can be found in every cell in the body, it has various functions as mentioned above. Primarily we see the effect of NAD+ when looking at ageing, as many ageing-related diseases are connected to the decrease of NAD+ that occurs as we get older. When we focus on fertility, NAD+ has an important role to play in egg quality as the quality of a person’s eggs is significantly dependent on their level of NAD+. A higher level of NAD+ is correlated to better egg quality, therefore, improved fertility.

The Research To Date On NAD+ And Fertility

Research conducted by the University of NSW in 2020 looked at the impact of NAD+ on the declining egg quality with age and whether this could be reversed through treatment using an NMN supplement in rats. The animal study found that although there are multiple factors that impact egg quality and fertility as we get older, a decreased level NAD+ is one of these factors and supplementing with NMN may be helpful in restoring egg quality.

In 2022, research was published in the journal of Reproductive Biology and Endocrinology looking into the effects of NAM (a slightly different precursor to NAD+ than NMN) on follicular development at different stages and the quality of eggs in women undergoing IVF.

The results found NAM concentration in mature follicular fluid was positively correlated with egg maturation and fertilization rates. The difference of which was statistically significant. The researchers speculated that increasing NAD+ has a beneficial role in enhancing egg maturation and fertilization capability. So while this research is in its infancy and we have many questions about optimal NAD+ levels, it presents positive results for NMN as a potential biomarker and nutritional supplement to support people experiencing subfertility.

The Dietoligist, Could NAD+ and NMN Help Improve Egg Quality & Fertility? – The Dietologist

Successful Pancreatic Cancer Story

Dear Laura, Tony, Kim and Becky, Thank you so much for being a critical part of my recovery from pancreatic cancer and for all your warm, caring and expert care.

Looking forward to being back for more of your lovely lollies!

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Introduction to Laura, Clinical Lead!

Laura is the owner of Positive IV Ltd and a fully qualified and registered nurse.
She has with over 10 years medical experience that includes extensive work in the community.
An advanced medical professional and fully certified nurse prescriber that will recommend and advise you on the best treatment options.
She is fully licensed and insured with a Bachelors and a Master Degree and currently studying as an Integrative Practitioner.